Horowitz Lyme Disease and other TBD'S.pdf

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LYME DISEASE AND OTHER
TBD’S
Designing Individualized Treatment
Regimens Based On
Symptomatology and Testing
Richard I. Horowitz, MD
Hudson Valley Healing Arts Center
Hyde Park, NY
845-229-8977
LD & Co-Infections:
Designing Individualized Treatment Regimens
•
Chronic Lyme Disease must be seen in the light of
multiple tick borne diseases, including HME,
HGE, Babesia, Bartonella, Mycoplasma,
Chlamydia, RMSF, Q-Fever, Tularemia, and Viral
infections (HHV6, HHV8, ? West Nile).
•
Symptoms of these diseases overlap and many
patients who have chronic ongoing
symptomatology who have failed classical
therapies for Lyme Disease may improve once all
co-infections are diagnosed and adequately
treated.
Investigative Treatment Protocols for
Lyme Disease and Multiple Co-infections
Immune
dysregulation:
ANA+, HLA DR4 +
Plaquenil
?Herbs / CAM tx
Tetracyclines
Cleocin & Quinine
Mepron&Zithromax
Lariam
Artemesia
Malarone
Diflucan, Acidophilus
Borrelia burgdorferi
Ehrlichia/Anapl.
Babesia
Bartonella
Viruses
? Mycoplasma
? Chlamydia
Cell Wall:
Penicillin /
Cephalosporins
Cyst: Flagyl/Plaquenil
Macrolides / Ketolides
Rifampin
Septra/Bactrim
Quinolones
?Neurotoxins
?HBOT
?Heat Therapy
?IV Glutathione
Anti-Virals
Candida:
Nystatin,
?Leaky Gut
?Food Allergies
?El syndrome,
Heavy metal
toxicities
?Multiple chemical
sensitivities
Hormonal d/f
Therefore, drug regimens which are effective against multiple
organisms simultaneously and penetrate intracellularly and into
the CNS may be necessary to achieve significant clinical
improvement.
Chronic Lyme Borreliosis Syndrome
•
•
Bb can persist in the body despite extensive courses of
antibiotics
A single tick bite can transmit multiple co-infections
(bartonella, babesia, ehrlichia, mycoplasma), which may
not be found on standard IFA testing.
Many of the co-infections are intracellular, protecting
them from short courses of antibiotics, making them
difficult to eradicate
Immune dysfunction / autoimmune overlap may be
common secondary to molecular mimicry, BLPs, Blebs,
HLA status
Neurotoxins (QUIN) / Bacterial toxins (Bb Tox1) may
be responsible for ongoing symptoms.
•
•
•
Chronic LB Syndrome: Problems with
Testing and Treatment
1)Intra and Interlaboratory Variation in LD
testing
-Bakken et al. JAMA 1992;268:891-895
-Magnarelli, LA. Laboratory diagnosis of Lyme
Disease. Rheum.Dis.Clin. North America 1989;
156;735-745
-There
are similar limitations to serological testing
for Bartonella, w/ false neg IFA’s
-Bergmans
et al. J Clin Microbiol 1997
-LaScala et al. J Clin Microbiol 1999
-Similarly,
Babesia testing often reveals neg IFA’s
with positive FISH and or PCR results

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