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Published on 09 December 2014 on http://pubs.rsc.org | doi:10.1039/9781782621836-FP001
Principles and Practice
The Handbook of Medicinal Chemistry
08:35:55.
Published on 09 December 2014 on http://pubs.rsc.org | doi:10.1039/9781782621836-FP001
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The Handbook of Medicinal Chemistry
Principles and Practice
08:35:55.
Published on 09 December 2014 on http://pubs.rsc.org | doi:10.1039/9781782621836-FP001
Edited by
Andrew Davis
¨
AstraZeneca, Molndal, Sweden
Email: andy.davis@astrazeneca.com
Simon E Ward
University of Sussex, Brighton, UK
Email: Simon.Ward@sussex.ac.uk
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08:35:55.
Published on 09 December 2014 on http://pubs.rsc.org | doi:10.1039/9781782621836-FP001
Print ISBN: 978-1-84973-625-1
PDF eISBN: 978-1-78262-183-6
A catalogue record for this book is available from the British Library
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The Royal Society of Chemistry 2015
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08:35:56.
Published on 09 December 2014 on http://pubs.rsc.org | doi:10.1039/9781782621836-FP005
Preface
Medicinal Chemistry sits at the heart of the pharmaceutical industry and the medicinal
chemist has one of the most challenging and rewarding jobs imaginable. The medicinal
chemist designs the drug which must balance often conflicting demands of a suitable dose,
by the chosen delivery route, at a desired dose frequency to provide a therapeutic effect while
maintaining margins to adverse effects throughout the dosing period. The drug molecule
may be given to millions of patients all of whom may respond to the drug differently, and all
of whom must be treated safely and effectively. Whilst drug discovery is undoubtedly an en-
deavour involving a wide range of scientific disciplines, the medicinal chemists are critical to
the design and progression of a drug molecule. It is the medicinal chemist who integrates
and balances the diverse inputs into a single chemical structure which has the potential to
become a new medicine.
This is an enormously difficult task. Our advances in synthetic organic chemistry mean that
we can respond well to the challenges of preparing and purifying new molecules and chemists
can be trained in these skills during undergraduate and graduate studies. In contrast, com-
pound design is far harder to control and requires extensive experience and knowledge to take
the sometimes subjective decisions to arrive at a potential drug candidate. There are few uni-
versal rules in drug design, and barely any universally accepted guidelines, and it sometimes
seems success is more a matter of chance. But, as Louis Pasteur said, ‘‘chance favours the
prepared mind’’. However, given the current challenges and high attrition during the devel-
opment phase, and the acceptance that many reasons for failure are directly attributable to the
chemical structure of the drug candidate, medicinal chemists have a duty to design the best
molecule possible to advance from research into development and beyond.
The aim of this book, through a series of monographs by leading scientists from across the
world, from major pharmaceutical companies, biotechnology companies, contract research
organisations and academia is to prepare the medicinal chemist to spot the good chances.
The book covers the whole R&D process from target validation through to late stage clinical
trials, through descriptions of the background science, the process, learnings, case studies,
leading references and even hints and tips.
The foreword has been written by one of our industry’s most respected scientists, Simon
Campbell CBE FRS, FMedSci. Simon Campbell joined Pfizer as a Medicinal Chemist in 1972,
and was a key member of the teams that led to such blockbuster drugs as Cardura, Norvasc and
Viagra. He went on to become Pfizer’s Senior Vice President for World-wide Drug Discovery and
Medicinal R&D in Europe. He was President of the Royal Society of Chemistry from 2004 to 2006
The Handbook of Medicinal Chemistry: Principles and Practice
Edited by Andrew Davis and Simon E Ward
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The Royal Society of Chemistry 2015
Published by the Royal Society of Chemistry, www.rsc.org
v

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