Abraham.D.J.[Burger's] - Medicinal Chemistry.Vol 3.pdf

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BURGER'S MEDICINAL
CHEMISTRY
AND
DRUG DISCOVERY
Sixth Edition
and Endocrines
Edited
by
4
Volume
3:
Cardiovascular Agents
Donald
J.
Abraham
Department of Medicinal Chemistry
School of Pharmacy
Virginia Commonwealth University
Richmond, Virginia
WILEY-
INTERSCIENCE
A john Wiley and Sons, Inc., Publication
PREFACE
Editors, Editorial Board Members, and
Wiley and Sons have worked for three
a half years to update the fifth edition of
ger's Medicinal Chemistry and Drug Dis-
wvery. The sixth edition has several new and
unique features. For the
first
time, there will
an online version of this major reference
rk. The online version
will
permit updating
and easy access. For the
first
time, all volumes
are structured entirely according to content
and published simultaneously. Our intention
was
to provide a spectrum of fields that would
new or experienced medicinal chem-
biologists, pharmacologists and molecu-
iologists entry to their subjects of interest
as
well
as
provide
a
current and global per-
spective of drug design, and drug develop-
Our hope was to make this edition of
Burger the most comprehensive and useful
published to date. To accomplish this goal, we
expanded the content from
69
chapters
(5
vol-
es) by approximately
50%
(to over
100
s in
6
volumes). We are greatly in debt
thors and editorial board members
icipating
in
this revision of the major ref-
work in our field. Several new subject
ave emerged since the fifth edition ap-
Proteomics, genomics, bioinformatics,
mbinatorial chemistry, high-throughput
screening, blood substitutes, allosteric effec-
tors as potential drugs, COX inhibitors, the
etatins, and high-throughput pharmacology
are
only a few. In addition to the new areas, we
have filled in gaps in the fifth edition by in-
cluding topics that were not covered. In the
sixth edition, we devote an entire subsection
of Volume
4
to cancer research; we have also
reviewed the major published Medicinal
Chemistry and Pharmacology texts to ensure
that we did not omit any major therapeutic
classes of drugs.
An
editorial board was consti-
tuted for the first time to also review and sug-
gest topics for inclusion. Their help was
greatly appreciated. The newest innovation in
this series will be the publication of an aca-
demic, "textbook-like" version titled, "Bur-
ger's Fundamentals of Medicinal Chemistry."
The academic text is to be published about a
year after this reference work appears.
It
will
also appear with soft cover. Appropriate and
key information will be extracted from the ma-
jor reference.
There are numerous colleagues, friends,
and associates to thank for their assistance.
First and foremost is Assistant Editor Dr.
John Andrako, Professor emeritus, Virginia
Commonwealth University, School of Phar-
macy. John and
I
met almost every Tuesday
for over three years to map out and execute
the game plan for the sixth edition. His contri-
bution to the sixth edition cannot be under-
stated. Ms. Susanne Steitz, Editorial Program
Coordinator
at
Wiley, tirelessly and meticu-
lously kept us on schedule. Her contribution
was also key in helping encourage authors to
return manuscripts and revisions so we could
publish the entire set at once.
I
would also like
to especially thank colleagues who attended
the QSAR Gordon Conference in
1999
for very
helpful suggestions, especially Roy Vaz, John
Mason, Yvonne Martin, John Block, and Hugo
,
Preface
Kubinyi. The editors are greatly indebted to
Professor Peter Ruenitz for preparing a tem-
plate chapter
as a
guide for all authors. My
secretary, Michelle Craighead, deserves spe-
cial thanks for helping contact authors and
reading the several thousand e-mails gener-
ated during the project.
I
also thank the com-
puter center
at
Virginia Commonwealth Uni-
versity for suspending rules on storage and
e-mail so that we might safely store all the
versions of the author's manuscripts where
they could be backed up daily. Last and not
least,
I
want to thank each and every author,
some of whom tackled two chapters. Their
contributions have provided our field with a
sound foundation of information to build for
the future. We thank the many reviewers of
"
manuscripts whose critiques have greatly en-
hanced the presentation and content for the
sixth edition. Special thanks to Professors
Richard Glennon, William Soine, Richard
Westkaemper, Umesh Desai, Glen Kel-
logg, Brad Windle, Lemont Kier, Malgorzata
Dukat, Martin Safo, Jason Rife, Kevin k e p -
olds, and John Andrako in our Department
of Medicinal Chemistry, School of Pharmacy,
Virginia Commonwealth University for sug-
gestions and special assistance in reviewing
manuscripts and text. Graduate student
Derek Cashman took able charge of our web
site,
http://www.burgersmedchem.com,
an-
other first for this reference work.
I
would es-
pecially like to thank my dean, Victor
Yanchick, and,Virginia Commonwealth Uni-
versity for their support and encouragement,
Finally,
I
thank my wife Nancy who under-
stood the magnitude of this project and pro-
vided insight on how to set up our home office
as well as provide John Andrako and me
lunchtime menus where we often dreamed of
getting chapters completed in all areas we se-
lected. To everyone involved, many, many
thanks.
D
ONALD
J .
A
BRAHAM
Midlothian, Virginia
Dr.
Alfred Burger
rhotograph or Professor Burger followed by his comments to the American Chemical Society 26th Medicinal
Chemistry Symposium on June 14, 1998. This was his last public appearance at a meeting of medicinal
chemists. As general chair of the 1998 ACS Medicinal Chemistry Symposium, the editor invited Professor
Burger to open the meeting. He was concerned that the young chemists would not know who he was and he
might have an attack due to his battle with Parkinson's disease. These fears never were realized and his
comments to the more than five hundred attendees drew a sustained standing ovation. The Professor was 93,
and
it was Mrs. Burger's 91st birthday.

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